Role of gut microbiota in the development of non-alcoholic fatty liver disease
作者机构：Department of Physiology and PathophysiologySchool of Basic Medical SciencesPeking UniversityThe Key Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijingChina
出 版 物：《Liver Research》 (肝脏研究（英文）)
年 卷 期：2019年第3卷第1期
页 面：25-30页
基 金：This work was supported by the National Key Research and Development Program of China(2016YFC0903100,2016YFC0903102) the National Natural Science Foundation of China(81522007,81470554,31401011) the Fundamental Research Funds for the Central Universities:Clinical Medicine Plus X-Young Scholars Project of Peking University(PKU2018LCXQ013).
主 题：Non-alcoholic fatty liver disease(NAFLD) Gut microbiota Bile acid Farnesoid X receptor(FXR) Ceramide Bile salt hydrolase(BSH)
摘 要：Non-alcoholic fatty liver disease(NAFLD)is a chronic liver disease characterized by hepatic steatosis in the absence of other causes,such as chronic alcohol consumption,that cause secondary hepatic fat accumulation.NAFLD has become the most common liver disease worldwide over the past two decades,and the prevalence of NAFLD is 20e30%in Western countries.However,the mechanism of NAFLD re-mains unclear.The gut microbiota plays an important role in the metabolism of the host;in fact,it has been implicated in inflammatory diseases,metabolic syndrome and cardiovascular disease.Accumu-lating evidence has indicated that gut microbiota component changes are linked to human obesity,in-sulin resistance(IR),type 2 diabetes and NAFLD.Here,we provide insight into the role of gut microbiota,especially bile salt hydrolase(BSH)in modulating the bile acid pool and farnesoid X receptor(FXR),which promotes the synthesis of ceramide and contributes to the development of NAFLD.
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