Serum Resistin Levels in Adult Patients with Nonalcoholic Fatty Liver Disease:A Systematic Review and Meta-analysis

作     者：Dongli Han Jie Chen Shousheng Liu Zengzhi Zhang Zhenzhen Zhao Wenwen Jin Yongning Xin Dongli Han;Jie Chen;Shousheng Liu;Zengzhi Zhang;Zhenzhen Zhao;Wenwen Jin;Yongning Xin

作者机构：Department of Infectious DiseaseQingdao Municipal HospitalDalian Medical UniversityDalianLiaoningChina Qingdao City Shinan District Centers for Disease Control and PreventionQingdaoShandongChina Clinical Research CenterQingdao Municipal HospitalQingdaoShandongChina Digestive Disease Key Laboratory of QingdaoQingdaoShandongChina 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2021年第9卷第4期

页      面：484-493页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study was supported by a grant from the National Natural Science Foundation of China(No.31770837) which plays a significant role in the design of the study and data collection,analysis nor interpretation,nor in the writing of the manuscript 

主　　题：Resistin Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Biomarker 

摘      要：Background and Aims:Previous studies reported that serum resistin levels were remarkably changed in patients with nonalcoholic fatty liver disease(NAFLD)but the conclusions were *** aim of this study was to investigate accurate serum resistin levels in adult patients with ***:A complete literature research was conducted in the PubMed,Embase,and Cochrane Library databases,and all the available studies up to 7 May 2020 were *** pooled standardized mean difference(SMD)values were calculated to investigate the serum resistin levels in patients with NAFLD and healthy ***:A total of 28 studies were included to investigate the serum resistin levels in patients with *** with NAFLD had higher serum resistin levels than controls(SMD=0.522,95%confidence interval[CI]:0.004–1.040,I2=95.9%).Patients with nonalcoholic steatohepatitis(NASH)had lower serum resistin levels than the healthy controls(SMD=−0.44,95%CI:−0.83–0.55,I2=74.5%).In addition,no significant difference of serum resistin levels was observed between patients with NAFL and healthy controls(SMD=−0.34,95%CI:−0.91–0.23,I2=79.6%)and between patients with NAFL and NASH(SMD=0.15,95%CI:−0.06–0.36,I2=0.00%).Furthermore,subgroup and sensitivity analyses suggested that heterogeneity did not affect the results of ***:This meta-analysis investigated the serum resistin levels in adult patients with NAFLD *** with NAFLD had higher serum resistin levels and patients with NASH had lower serum resistin levels than healthy *** resistin could serve as a potential biomarker to predict the development risk of NAFLD.