A moonlighting function of choline kinase alpha 2 in the initiation of lipid droplet lipolysis in cancer cells
作者机构：Qingdao Cancer InstituteThe Affiliated Hospital of Qingdao UniversityQingdaoShandong 266071P.R.China Zhejiang Provincial Key Laboratory of Pancreatic Diseasethe First Affiliated HospitalInstitute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiang 310029P.R.China Cancer CenterZhejiang UniversityHangzhouZhejiang 310029P.R.China State Key Laboratory of Oral DiseasesNational Clinical Research Center for Oral DiseasesChinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and ManagementWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041P.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2021年第41卷第10期
页 面：933-936页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：metabolism invasion Cancer
摘 要：Cancer cells in the tumormicroenvironment,where nutrient availability is consistently changing during tumor progression,harness lipid metabolism to support their proliferation,survival,migration,invasion,and metastasis[1].When nutrients in the tumor microenvironment are sufficient,lipids such as triglycerides,steryl esters,and retinyl esters are stored in lipid droplets,which are dynamic lipid-rich cellular organelles surrounded by a single layer of polar and amphipathic phospholipids and structural proteins in the perilipin(PLIN)family.
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