Design, Synthesis and <i>in Vitro</i>Antibacterial Activity of 2-thiomethyl-benzimidazole Derivatives

作     者：Ablo Evrard Coulibali Siomenan Camara Tchambaga Etienne Toure Daouda Coulibaly Souleymane Sissouma Drissa Adjou Ané Ablo Evrard;Coulibali Siomenan;Camara Tchambaga Etienne;Toure Daouda;Coulibaly Souleymane;Sissouma Drissa;Adjou Ané

作者机构：Laboratoire de Constitution et Réaction de la Matière UFR Sciences des Structures de la Matière et Technologie Université Félix Houphouë t Boigny de Cocody Abidjan Cô te d’Ivoire Département de Biologie UFR des Sciences Biologiques Université Peleforo Gon Coulibaly Korhogo Cô te d’Ivoire 

出 版 物：《Advances in Biological Chemistry》 (生物化学进展（英文）)

年 卷 期：2021年第11卷第4期

页      面：165-177页

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

主　　题：Antibacterial Activity Benzimidazole 2-Methylbenzimidazole Thiouronium Halide 

摘      要：A series of novel substituted benzimidazole (7a-n) derivatives were synthesized and characterized by 1H, 13C Nuclear Magnetic Resonance (NMR) spectra and High Resolution Mass Spectrometry (HRMS). The substitution was done in position -1 and -2 by appropriate groups. These compounds are obtained by N-alkylation reaction with thiomethyl-1H-benzimidazole intermediates (5a-g). Design of intermediates (5a-g) was made by condensation reaction between 2-methylbenzimidazole thiourunium salt span styl