Autologous Adipose-Derived Mesenchymal Stem Cells Embedded in Platelet-Rich Fibrin in Diabetic Foot Ulcers
Autologous Adipose-Derived Mesenchymal Stem Cells Embedded in Platelet-Rich Fibrin in Diabetic Foot Ulcers作者机构：Reviva Stem Cell Platform for Research and Applications Center Bsalim Lebanon Middle East Institute of Health University Hospital Bsalim Lebanon Faculty of Pharmacy Saint Joseph University Beirut Lebanon National Institute of Health and Medical Research INSERM Paris Sud France Faculty of Pharmacy Therapeutic Innovation from Fundamentals to Applications Paris Saclay University Chä tenay Malabry France Faculty of Medicine Lebanese University Beirut Lebanon School of Medicine Lebanese American University Beirut Lebanon Michigan Medicine Speciality Pharmacy Ann Arbor MI USA Cancer Center Middle East Institute of Health University Hospital Bsalim Lebanon
出 版 物：《Open Journal of Regenerative Medicine》 (再生医学期刊（英文）)
年 卷 期：2021年第10卷第2期
页 面：19-30页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Diabetic Foot Ulcer Diabetes Mesenchymal Stem Cells Adipose Tissue Platelet Rich Fibrin
摘 要：Context and Aim: Mesenchymal stem cells (MSCs) and platelet-rich fibrin (PRF) have emerged as ideal candidates for advanced therapies of various therapeutically-challenging diseases;however, their regenerative potential in diabetic foot ulcers (DFU) has not been well determined. In this study, we reviewed our clinical experience in mitigating chronic ulcer complications of diabetic foot through a conventional treatment of autologous adipose-derived MSCs embedded in PRF with pure PRF injections. Materials and Methods: The present study was carried out in 10 patients with an open DFU wound selected over a period of 1 year starting from April 2019. Patients were either injected with PRF alone (Group A) or injected with MSCs derived from adipose tissue (ADMSC) embedded in (PRF (Group B). Results: Patients in Group B had a better healing index when compared to Group A. Conclusion: Use of ADMSC embedded in PRF showed promising results to treat DFU.
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