Identification of Nonalcoholic Fatty Liver Disease following Pancreatic Surgery in a Western Cohort Using a Novel Radiographic Technique
Identification of Nonalcoholic Fatty Liver Disease following Pancreatic Surgery in a Western Cohort Using a Novel Radiographic Technique作者机构：Department of Internal MedicineWarren Alpert Medical School of Brown UniversityProvidenceRIUSA Department of Diagnostic ImagingWarren Alpert Medical School of Brown UniversityProvidenceRIUSA Department of SurgeryWarren Alpert Medical School of Brown UniversityProvidenceRIUSA Division of Gastroenterology and HepatologyWarren Alpert Medical School of Brown UniversityProvidenceRIUSA
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2015年第3卷第4期
页 面：246-253页
主 题：Retrospective cohort NAFLD Whipple Distal pancreatectomy
摘 要：Background and Aims:While traditional risk factors for the development of nonalcoholic fatty liver disease(NAFLD)relate to metabolic syndrome,several Asian studies have suggested a high rate of de novo NAFLD following pancreaticoduodenectomy(PD).The aim of this study is to identify de novo NAFLD after pancreatic surgery and its associated risk factors.Methods:A retrospective cohort of patients at a single center that underwent PD or distal pancreatectomy(DP)over 7 years was identified.Pre-and postoperative contrast-enhanced computed tomography scans of the abdomen were reviewed,including attenuation measurements of the liver,spleen,and muscle.Primary outcomes included hepatic attenuation,liver to muscle ratio(LMR),and liver to spleen ratio(LSR).Results:Of the 96 patients(mean age 64.3)included,70%underwent PD,and 30%underwent DP.The mean LMR decreased significantly from 1.81 to 1.66(p=0.02),noted only in men.No interaction effect with LMR was observed with surgical type,chemotherapy,blood loss,pancreatic enzyme replacement,or transaminases.LMR decreased In 55%of subjects.Conclusions:Increased fatty infiltration,as evidence by decreased LMR,was found among men that underwent PD and DP within a year of surgery.This may be related to weight loss and malabsorption and deserves further investigation.
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