The potent roles of salt-inducible kinases(SIKs)in metabolic homeostasis and tumorigenesis
作者机构：Institute of Precision Medicinethe First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510275China Department of Breast and Thyroid Surgerythe First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510275China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：1141-1155页
核心收录：
学科分类：0710[理学-生物学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 100602[医学-中西医结合临床]
基 金：supported by National Nature Science Foundation of China(NSFC)to J.G.(31871410) the Guangdong Science and Technology Department Fund to J.L.(2016A040403049 and 2017A010105029).
主 题：tumorigenesis homeostasis kinases
摘 要：Salt-inducible kinases(SIKs)belong to AMP-activated protein kinase(AMPK)family,and functions mainly involve in regulating energy response-related physiological processes,such as gluconeogenesis and lipid metabolism.However,compared with another well-established energy-response kinase AMPK,SIK roles in human diseases,especially in diabetes and tumorigenesis,are rarely investigated.Recently,the pilot roles of SIKs in tumorigenesis have begun to attract more attention due to the finding that the tumor suppressor role of LKB1 in non-small-cell lung cancers(NSCLCs)is unexpectedly mediated by the SIK but not AMPK kinases.Thus,here we tend to comprehensively summarize the emerging upstream regulators,downstream substrates,mouse models,clinical relevance,and candidate inhibitors for SIKs,and shed light on SIKs as the potential therapeutic targets for cancer therapies.
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