May mesenchymal stem cell transplantation be a solution for COVID-19 induced cytokine storm?

作     者：Hüseyin Sütlüoğlu ÖnerÖzdemir 

作者机构：Faculty of MedicineSakarya UniversityAdapazarı54100SakaryaTurkey Division of Pediatric Allergy and ImmunologySakarya University Medical FacultyAdapazarı54100SakaryaTurkey 

出 版 物：《World Journal of Transplantation》 (世界移植杂志)

年 卷 期：2021年第11卷第8期

页      面：344-355页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Mesenchymal stem cell Mesenchymal stromal cell COVID-19 Cytokine storm Immunosuppression Transplantation 

摘      要：The recently emergent disease caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),transmitted by droplets and aerosols,was named coronavirus disease 2019(COVID-19)by World Health ***,the disease progress is asymptomatic or mild,but one-fifth of the patients advance to severe or critical *** severe COVID-19 patients,type-2 T helper cells release numerous cytokines;this excessive immune response is named as cytokine *** cytokine storm,which is the hallmark of the COVID-19 induced by the disease and aggravates due to lack of proper immune response,similar to SARS and Middle East respiratory syndrome(MERS),and the disease status may progress forward to acute respiratory distress syndrome(ARDS),systemic inflammatory response syndrome,multi-organ dysfunction syndrome,and *** stromal cell transplantation is up-and-coming in treating many diseases such as HIV,hepatitis B,influenza,coronavirus diseases(SARS,MERS),lung injuries,and *** closer inspection on respiratory diseases,COVID-19,influenza,SARS,and MERS have similarities in patho-genesis,especially cytokine and immune response *** comparable features in terms of the cytokine storm will provide hints for the treatment of COVID-19.