Functional and immunological peculiarities of peripheral nerve allografts

作     者：Kelly C.S.Roballo Jason P.Gigley Tyler A.Smith George D.Bittner Jared S.Bushman Kelly C.S.Roballo;Jason P.Gigley;Tyler A.Smith;George D.Bittner;Jared S.Bushman

作者机构：School of PharmacyUniversity of WyomingLaramieWYUSA Department of Molecular BiologyUniversity of WyomingLaramieWYUSA Department of Molecular BiosciencesUniversity of Texas at AustinAustinTXUSA Department of NeuroscienceUniversity of Texas at AustinAustinTXUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第4期

页      面：721-727页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by University of Wyoming Startup Funds,United States Department of Defense,grant No.W81XWH-17-1-0402 the University of Wyoming Sensory Biology COBRE under National Institutes of Health(NIH),award number 5P20GM121310-02 the National Institute of General Medical Sciences of the NIH under Award Number P20GM103432(to JSB) the Lone Star Paralysis Foundation,NIH R01NS081063 Department of Defense award W81XWH-19-2-0054 to GDB 

主　　题：allograft animal model immunology neuroimmunology peripheral nerve injury regeneration repair tissue regeneration tissue transplantation transplant 

摘      要：This review addresses the accumulating evidence that live(not decellularized)allogeneic peripheral nerves are functionally and immunologically peculiar in comparison with many other transplanted allogeneic *** is relevant because live peripheral nerve allografts are very effective at promoting recovery after segmental peripheral nerve injury via axonal regeneration and axon *** the immunological peculiarities of peripheral nerve allografts may also be of interest to the field of transplantation in *** topics are addressed:The first discusses peripheral nerve injury and the potential utility of peripheral nerve allografts for bridging segmental peripheral nerve defects via axon fusion and axon *** second reviews evidence that peripheral nerve allografts elicit a more gradual and less severe host immune response allowing for prolonged survival and function of allogeneic peripheral nerve cells and ***,potential mechanisms that may account for the immunological differences of peripheral nerve allografts are discussed.