Mufolinin A,an unprecedented ring A-seco 10-ethyllimonoid from Munronia unifoliolata

作     者：Yunpeng Sun Letian Cui Qiurong Li Pengfei Tang Yongyi Li Wenjun Xu Jun Luo Lingyi Kong Yunpeng Sun;Letian Cui;Qiurong Li;Pengfei Tang;Yongyi Li;Wenjun Xu;Jun Luo;Lingyi Kong

作者机构：Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural MedicinesSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第1期

页      面：516-518页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the National Natural Science Foundation of China(No.31470416) the 111 Project from Ministry of Education of China and the State Administration of Foreign Export Affairs of China(No.B18056).ll supported in part by SciGrid,Chinese Academy of Sciences 

主　　题：Meliaceae Munronia unifoliolata Limonoids Anti-inflammatory Anti-multidrug resistance 

摘      要：Mufolinin A(1),a ring A-seco rearranged limonoid with an unprecedented ethyl at C-10 and novel 6/6/6/5 fused-ring skeleton,together with three new potential precursors(ring A-seco limonoids,2–4)were isolated from Munronia *** structures and absolute configurations were confirmed by nuclear magnetic resonance(NMR),high resolution electrospray ionization mass spectroscopy(HRESIMS),X-ray crystallography,electronic circular dichroism(ECD)calculations and NMR calculations with DP4+*** unprecedented ethyl group of 1 was hypothesized to be derived from methyl migration and ring reduction rearrangement of ring A-seco limonoid *** 2 and 4 showed significant multidrug resistance(MDR)reversal activities in MCF-7/DOX cells with reversal fold(RF)values of 13.1 and 8.0,respectively.