Pharmaceutical strategies to extend pulmonary exposure of inhaled medicines

作     者：Yi Guo Hriday Bera Changzhi Shi Li Zhang Dongmei Cun Mingshi Yang Yi Guo;Hriday Bera;Changzhi Shi;Li Zhang;Dongmei Cun;Mingshi Yang

作者机构：Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Department of PharmacyFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen 2100Denmark 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第8期

页      面：2565-2584页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the Liaoning Pan Deng Xue Zhe scholarship for the financial support(China) Dongmei Cun thanks the financial support from the Guiding Project for Science and Technology of Liaoning Province(No.2019-ZD-0448,China) Minister of Education Chunhui Program(China) Hriday Bera thanks the National Natural Science Foundation of China(Nos.81850410554 and 82050410448) 

主　　题：Pulmonary drug delivery Pulmonary clearance pathways Pulmonary exposure Pharmaceutical strategies Inhaled sustained release formulations Local lung diseases Systemic diseases Pulmonary safety 

摘      要：Pulmonary administration route has been extensively exploited for the treatment of local lung diseases such as asthma,chronic obstructive pulmonary diseases and respiratory infections,and systemic diseases such as *** inhaled medicines could be cleared rapidly from the lungs and their therapeutic effects are *** inhaled medicines with extended pulmonary exposure may not only improve the patient compliance by reducing the frequency of drug administration,but also enhance the clinical benefits to the patients with improved therapeutic *** article systematically reviews the physical and chemical strategies to extend the pulmonary exposure of the inhaled *** starts with an introduction of various physiological and pathophysiological barriers for designing inhaled medicines with extended lung exposure,which is followed by recent advances in various strategies to overcome these ***,the applications of the inhaled medicines with extended lung exposure for the treatment of various diseases and the safety concerns associated to various strategies to extend the pulmonary exposure of the inhaled medicines are summarized.