Longitudial observation of dynamic changes in cortical function and white matter fibrous structure of patients with visual pathway lesions by blood oxygenation level dependent-functional magnetic resonance imaging combined with diffusion tensor imaging

作     者：Hui Xiao Ziqian Chen Gennian Qian Ping Ni Youqiang Ye Jinhua Chen 

作者机构：Department of MedicalRadiology Fuzhou GeneralHospital of Nanjing MilitaryArea Command of ChinesePLA Fuzhou 350025Fujian Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2007年第2卷第8期

页      面：449-454页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

主　　题：magnetic resonance imaging vision rehabilitation 

摘      要：BACKGROUND： Functional magnetic resonance imaging （fMRI） is initially used for visual cortex location. However, the application of fMRI in investigating the development of visual pathway lesions needs to be further observed. OBJECTIVE： This study is to longitudially observe the dynamic changes in cortical function and white matter fibrous structure of patients with visual pathway lesions by blood oxygenation level dependent-functional magnetic resonance imaging （BOLD-fMRI） combined with diffusion tensor imaging （DTI）, and to analyze the characteristics of brain function and structural recombination at convalescent period of lesions. DESIGN： Randomized controlled observation. SETTING： Department of Radiology, the General Hospital of Nanjing Military Area Command of Chinese PLA. PARTICIPANTS： Eight patients with unilateral or bilateral visual disorder caused by visual pathway lesions, who admitted to Department of Radiology, the General Hospital of Nanjing Military Area Command of Chinese PLA from January to September 2006 were involved, and served as experimental subjects. The patients, 6 males and 2 females, were aged 16 - 67 years. They had visual disorder confirmed by clinical examination, i.e. visual pathway lesion, which was further diagnosed by MR or CT. Another 12 subjects generally matching to those patients of experimental group in gender, age and sight, who received health examination in synchronization were involved and served as controls. The subjects had no history of eye diseases. Their binocular visual acuity （or corrected visual acuity） was over 1.0. Both routine examination of ophthalmology and examination of fundus were normal. Informed consents of detected items were obtained from all the subjects. METHODS： Signa Excite HD 1.5T magnetic resonance imaging system with 16 passages （GE Company, USA） and coil with 8 passages were used; brain functional stimulus apparatus （SAV-8800. Meide Company） was used for showing experimental mission. At the early s