Cancer biology deciphered by single-cell transcriptomic sequencing

作     者：Yanmeng Li Jianshi Jin Fan Bai Yanmeng Li;Jianshi Jin;Fan Bai

作者机构：Biomedical Pioneering Innovation Center(BIOPIC)School of Life SciencesPeking UniversityBeijing 100871China RIKEN Center for Biosystems Dynamics Research(BDR)6-2-3FuruedaiSuitaOsakaJapan Beijing Advanced Innovation Center for Genomics(ICG)Peking UniversityBeijing 100871China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2022年第13卷第3期

页      面：167-179页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 071009[理学-细胞生物学] 09[农学] 100214[医学-肿瘤学] 0901[农学-作物学] 090102[农学-作物遗传育种] 10[医学] 

基　　金：This work was financially supported by the National Science and Technology Major Project(2019YFC1315702) the Guangdong Province Key Research and Development Program(2019B020226002) 

主　　题：single-cell transcriptomic sequencing tumor microenvironment cancer 

摘      要：Tumors are complex ecosystems in which heterogeneous cancer cells interact with their microenvironment composed of diverse immune,endothelial,and stromal *** biology had been studied using bulk genomic and gene expression profiling,which however mask the cellular diversity and average the variability among individual molecular *** advances in single-cell transcriptomic sequencing have enabled a detailed dissection of tumor ecosystems and promoted our understanding of tumorigenesis at single-cell *** the present review,we discuss the main topics of recent cancer studies that have implemented singlecell RNA sequencing(scRNA-seq).To study cancer cells,scRNA-seq has provided novel insights into the cancer stem-cell model,treatment resistance,and cancer *** study the tumor microenvironment,scRNA-seq has portrayed the diverse cell types and complex cellular states of both immune and non-immune cells interacting with cancer cells,with the promise to discover novel targets for future immunotherapy.