Catalytic[3+3]Annulation ofβ-Ketoethers and Cyclopropenones via C(sp^(3))-O/C-C Bond Cleavage under Transition-Metal Free Conditions

作     者：Dachang Bai Junyan Chen Bingbing Zheng Xueyan Li Junbiao Chang Dachang Bai;Junyan Chen;Bingbing Zheng;Xueyan Li;Junbiao Chang

作者机构：NMPA Key Laboratory for Research and Evaluation of Innovative DrugCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007 China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第10期

页      面：2769-2773页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the NSFC(Nos.21801067,U1804283,21801066) the Central Plains scholars and ScientistsStudio Fund(No.2018002) the Project funded by the NaturalScience Foundation of Henan Province(Nos.202300410225,212300410181 and 201901023) the China Postdoctoral Science Foundation(Nos.2020T130176 and 2020M682306) 

主　　题：C-O/C-C activation [3+3]Annulation β-Ketoethers Cyclopropenones Transition-metal free conditions 

摘      要：Main observation and conclusion The efficient cleavage of carbon-oxygen(C—O)bond is highly important for the transformation of oxygen-rich biomass and industry ***,an efficient[3+3]annulation ofβ-ketoethers with cyclopropenones in the presence of catalytic base has been developed,which proceeds through the C(sp^(3))—O bonds cleavage inβ-ketoethers and C—C bond cleavage in cyclopropenones under transition-metal free *** cleavage of C(sp^(3))—O bonds in alkyl alkyl ethers and aryl alkyl ethers was *** reaction featured excellent functional group compatibility and chemoselectivity,affording various 2-pyrones in good to excellent yields under mild conditions and simple operation.