Pathological mechanisms and therapeutic strategies for Alzheimer's disease

作     者：Yaojun Ju Kin Yip Tam Yaojun Ju;Kin Yip Tam

作者机构：Faculty of Health SciencesUniversity of MacaoAvenida de UniversidadeTaipaMacao Special Adiministrative RegionChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第3期

页      面：543-549页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：funded by University of Macao (File No.MYRG2016-00102-FHS)(to KYT) 

主　　题：Alzheimer's disease pathological pathways drug development multiple pathologies 

摘      要：Alzheimer s disease is a rather complex neurodegenerative disease,which is attributed to a combination of multiple *** the many pathological pathways,synaptic dysfunctions,such as synapses loss and deficits in synaptic plasticity,were thought to be strongly associated with cognitive *** deficiencies in various sorts of neurotransmissions are responsible for the multifarious neurodegenerative symptoms in Alzheimer s disease,for example,the cholinergic and glutamatergic deficits for cognitive decline,the excitatory and inhibitory neurotransmission dyshomeostasis for synaptic plasticity deficits and epileptiform symptoms,and the monoamine neurotransmission for neuropsychiatric *** cascade hypothesis is the most popular pathological theory to explain Alzheimer s disease pathogenesis and attracts considerable *** lines of genetic and pathological evidence support the predominant role of amyloid beta in Alzheimer s disease *** tangles assembled by microtubule-associated protein tau are other important histopathological characteristics in Alzheimer s disease *** of tau toxicity was proved to lead to neuron damage,neuroinflammation and oxidative stress in *** is the main risk factor of neurodegenerative diseases,and is associated with inflammation,oxidative stress,reduced metabolism,endocrine insufficiencies and organ *** aging related risk factors were also proved to be some of the risk factors contributing to Alzheimer s *** Alzheimer s disease drug development,many good therapeutic strategies have been investigated in clinical ***,complex mechanism of Alzheimer s disease and the interplay among different pathological factors call for the come out of allpowerful therapies with multiple curing *** review seeks to summarize some of the representative treatments targeting different pathological pathways currently under clinical ***