Pregnancy,Pancreatitis,and Hypoglycemia:Multi-modal Management in a Case with Multiple Endocrine Neoplasia-1 Syndrome

作     者：Anshita Aggarwal Aditya Dutta Sanjay K.Bhadada Anil Bhansali 

作者机构：Department of EndocrinologyPostgraduate Institute of Medical Education and ResearchChandigarh 160012India 

出 版 物：《Maternal-Fetal Medicine》 (母胎医学杂志（英文）)

年 卷 期：2021年第3卷第3期

页      面：221-224页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学] 

主　　题：Pregnancy Hypercalcemia Parathyroid adenoma Insulinoma MEN-1 

摘      要：A 32-year-old lady presented to us at 6 months of gestation with acute pancreatitis due to parathyroid hormone-dependent hypercalcemia and with insulin-dependent hypoglycemia,owing to parathyroid adenoma and possibly insulinoma,*** parathyroid adenoma was localized on the magnetic resonance imaging of the neck;however,imaging for the insulinoma could not be done due to the gravid *** to the simultaneous occurrence of tumours in two endocrine glands,namely,parathyroid gland and pancreatic islet cells,a diagnosis of MEN-1(multiple endocrine neoplasia)was considered,which is very rarely seen in *** hypercalcemia was effectively managed with cinacalcet and alcohol ablation of the parathyroid adenoma while her hypoglycemic episodes were managed with short and long-acting octreotide injections during the antenatal *** had a full-term cesarean delivery,with no maternal or neonatal complications,except for transient neonatal *** patient was followed up for 1 year after her delivery with no further episodes of hypercalcemia and hypoglycemia,on medical ***99m sestamibi scan was done after delivery which confirmed the presence of a left inferior parathyroid ***-1 with pregnancy thus poses a diagnostic and therapeutic challenge and our case highlights the role of multimodal medical therapy for successful management.