Treatment strategies for hepatocellular carcinoma with extrahepatic metastasis
作者机构：Department of Medical UltrasonicsInstitute of Diagnostic and Interventional Ultrasoundthe First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Medical OncologyThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2021年第9卷第21期
页 面：5754-5768页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Natural Science Foundation of Guangdong Province of China,No.2018A0303130165 Science and Technology Program of Guangzhou,No.201904010046
主 题：Hepatocellular carcinoma Extrahepatic metastasis Systemic therapy Targeted therapy Immunotherapy Locoregional therapy
摘 要：Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)has increasingly been seen due to improved survival with effective management of intrahepatic *** presence of EHM indicates an advanced stage of HCC,for which systemic therapy serves as the standard treatment *** the approval of Sorafenib as the first systemic agent in 2007,it took almost a decade to show its efficacy in both first and further lines of setting until the landscape of systemic drugs was finally ***,with inspiring results from immunotherapy trials in HCC,it appears that the introduction of immunotherapy may lead to an evolution in the portfolio of HCC *** the locoregional approach in the management of EHM is not recommended for advancedstage HCC,efforts have been made to demonstrate its efficacy in symptom relief and potential benefit for overall *** review provides a summary of recent updates of the systemic agents in the treatment of advanced HCC,with an emphasis on aggressive locoregional management of EHM by various treatment modalities.
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