Preeclampsia: A Review of Early Predictors

作     者：Riwa A.Abbas Labib Ghulmiyyah Elie Hobeika Ihab M.Usta Fadi Mirza Anwar H.Nassar 

作者机构：Department of Obstetrics and GynecologyAmerican University of Beirut Medical CenterBeirut 11072020Lebanon 

出 版 物：《Maternal-Fetal Medicine》 (母胎医学杂志（英文）)

年 卷 期：2021年第3卷第3期

页      面：197-202页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：Pre-eclampsia Doppler studies Early prediction Pregnancy complications Serum biomarkers 

摘      要：Preeclampsia is a progressive,multi-system disorder of pregnancy associated with morbidity and mortality on both the mother and the ***,research is directed at identifying early biomarkers of preeclampsia in order to predict its *** is important because it helps understand the pathophysiology of the disease,and thus,promises new treatment *** a clear understanding of the pathogenesis of PE remains elusive,the currently most accepted theory suggests a two-stage *** first stage results in inadequate remodeling of the spiral arteries and leads to the second stage,whereby the clinical features of the syndrome are *** this review,we summarize the modalities that have been studies so far to predict *** use of uterine artery Doppler and several other biomarkers such as vitamin D,soluble fms-like tyrosine kinase 1/placental growth factor(sFLT1/PIGF)ratio,soluble endoglin,and a subset of T-lymphocytes has shown promising *** are still at early stages in this advance,and no clear recommendations have been made about their clinical use to *** studies are still needed to improve screening strategies and evaluate the cost-effectiveness of any intervention.