Pd(II)and Rh(III)Complexes with Isoquinoline Derivatives Induced Mitochondria-Mediated Apoptotic and Autophagic Cell Death in HepG2 Cells

作     者：Noor Shad Gul Taj-Malook Khan Yan-Cheng Liu Muhammad Iqbal Choudhary Zhen-Feng Chen Hong Liang 

作者机构：State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesSchool of Chemistry and PharmacyGuangxi Normal UniversityGuilin 541004 International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 74270 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2021年第3卷第6期

页      面：1626-1641页

学科分类：07[理学] 0703[理学-化学] 

基　　金：This work was supported by the National Natural Science Foundation of China(grant no.21431001) IRT_16R15,and Natural Science Foundation of Guangxi Province of China(grant nos.2016GXNSFGA380005 and AD17129007)as well as the“BAGUI Scholar”program of Guangxi Province of China 

主　　题：palladium(II) rhodium(III) isoquinoline derivatives anticancer apoptosis autophagy 

摘      要：Nonplatinummetal complexes of[Pd(L^(1))Cl_(2)](C1),[Rh(L^(1))Cl_(3)(DMSO)](C2),[Pd(L^(2))Cl_(2)](C3),and[Rh(L^(3))Cl_(3)(DMSO)](C4)with isoquinoline derivatives have been prepared and characterized.C1-C4 exhibited higher in vitro anticancer activity and lower toxicity than the corresponding ligands and cisplatin against HepG2 *** mechanistic studies revealed that C1 arrested the cell cycle at S-phase by regulation of cyclin and cyclin-dependent kinases.C1 was accumulated in mitochondria,which increased the generation of reactive oxygen species(ROS)and endoplasmic reticulum(ER)-stress response through mitochondrial ***,C1 stimulated Ca^(2+)release,activated the caspase cascade,and triggered mitochondria-mediated *** in vivo studies of C1 demonstrated higher safety than cisplatin and effective tumor growth inhibition.C1 is a potential anticancer drug candidate.