When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance
作者机构：Department of Clinical Laboratory Sciences and Medical BiotechnologyCollege of MedicineNational Taiwan UniversityTaipei 10048TaiwanChina Department of Diabetes Complications and MetabolismDiabetes and Metabolism Research InstituteBeckman Research InstituteCity of HopeDuarteCA 91010USA Irell and Manella Graduate School of Biological SciencesCity of HopeDuarteCA 91010USA
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2018年第38卷第1期
页 面：499-510页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported in part by funds from the National Institutes of Health R01DE026304 and R01CA220693(to D.K.A.) Ministry of Science and Technology,R.O.C,Special Talents Award(to C.-Y.K).
主 题：Fatty acid synthesis Fatty acid oxidation Fatty acid metabolism Lipogenic phenotype Cancer stem cells Tumor-initiating cells Cancer cell plasticity Therapeutic resistance Drug-tolerant persisters
摘 要：The role of fatty acid metabolism,including both anabolic and catabolic reactions in cancer has gained increas-ing attention in recent years.Many studies have shown that aberrant expression of the genes involved in fatty acid synthesis or fatty acid oxidation correlate with malignant phenotypes including metastasis,therapeutic resistance and relapse.Such phenotypes are also strongly associated with the presence of a small percentage of unique cells among the total tumor cell population.This distinct group of cells may have the ability to self-renew and propagate or may be able to develop resistance to cancer therapies independent of genetic alterations.Therefore,these cells are referred to as cancer stem cells/tumor-initiating cells/drug-tolerant persisters,which are often refractory to cancer treatment and difficult to target.Moreover,interconversion between cancer cells and cancer stem cells/tumor-initiating cells/drug-tolerant persisters may occur and makes treatment even more challenging.This review highlights recent findings on the relationship between fatty acid metabolism,cancer stemness and therapeutic resistance and prompts discussion about the potential mechanisms by which fatty acid metabolism regulates the fate of cancer cells and therapeutic resistance.
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