Magnetic Ganoderma Lucidum Spores(mGLS):A Novel Regulatable Targeted Drug Delivery System

作     者：Bin Han Zhankun Weng Yuhan Wu Xin Zhao Jingmei Li Qinhan Zhang Kaige Qu Bojian Liang Fenguo Zhou Guixia Liu Zuobin Wang Bin Han;Zhankun Weng;Yuhan Wu;Xin Zhao;Jingmei Li;Qinhan Zhang;Kaige Qu;Bojian Liang;Fenguo Zhou;Guixia Liu;Zuobin Wang

作者机构：Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturings Changchun University of Science and TechnologyChangchun 130022China International Research Centre for Nano Handling and Manufacturing of ChinaChangchun University of Science and TechnologyChangchun 130022China School of Life SciencesChangchun University of Science and TechnologyChangchun 130022China Department of Orthopaedic SurgeryChina-Japan Union Hospital of Jilin UniversityChangchun 130033China School of Chemistry and Environmental EngineeringChangchun University of Science and TechnologyChangchun 130022China 

出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)

年 卷 期：2021年第18卷第4期

页      面：915-926页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：This work was supported by National Key R&D Program of China(No.2018YFB1105400) Jilin Provincial Science and Technology Program(Nos.20190702002GH,2020C022-1,and YDZJ202102CXJD 007) Programme of Introducing Talents of Discipline to Universities(D17017) 

主　　题：Magnetic Ganoderma Lucidum Spores(mGLS) sustained release 5-FU drug delivery 

摘      要：In the past decades,many materials have been studied as carriers for targeted drug ***,there is a need for utilizable and selective carrier materials with few side ***,the magnetic Ganoderma Lucidum Spores(mGLS)as a highly efficient targeted drug delivery carrier were *** the regulatable targeted drug delivery system was verified by loading and releasing of the 5-Fluorouracil(5-FU).The results showed that the maximum of the loaded 5-FU reached 250.23 mg·g^(−1)in the *** cumulative release of the 5-FU for the drug delivery system could reach 80.11%and 67.14%in the PBS and HCl after 48 h,*** addition,this system showed the good pharmacokinetic properties in *** 12 h,the blood concentration in the 5-FU@mGLS group kept at 5.3µg·mL^(−1)and was four times higher than that in the 5-FU *** summary,the GLS as a natural microscale core-shell structures appears the striking application in carrier material for oral drug delivery.