恶性非霍奇金淋巴瘤伴Garcin综合征(法国)
Malignant non- Hodgkin lymphoma presenting with Garcin’s syndrome (Fren)作者机构：Départementde Neurologie CHU 49033 Angers Cedex France
出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)
年 卷 期：2005年第1卷第4期
页 面：51-51页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Garcin 非霍奇金淋巴瘤 颅神经受累 第Ⅷ颅神经 死亡诊断 颅神经麻痹 淋巴细胞计数 常规尸检 神经病理学 Ⅹ颅神经
摘 要：Introduction. R Garcin described progressive unilateral cranialnerve palsy in 1926. Garcin syndrome is characterized by progressive involvement of the cranial nerves culminating intotal unilateral paralysis of all cranial nerves. Carcinoma of the skull base or ENT regions is the most common *** report. A 74- year- old man developed signs involving the left Vth (V2 and V3) cranial nerve then the VIth, VIIth and VIIIth cranial nerves and finally the IXth and Xth. MRI showed involvement of these cranial nerves with gadolinium uptake and involvement of the pons at the terminal phase. Careful ENT explorations failed to reveal a cause. The lymphocyte count was elevated in the cerebrospinal fluid. The patient died one year after diagnosis and the general autopsy was normal. The neuropathological studies led to the post- mortem diagnosis of type B non- Hodgkin lymphoma. Conclusion. In patients with Garcin syndrome, lymphoma is a possible diagnosis when carcinoma of the ENT regions or of the skull bases are not present.
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