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Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuringβ-Cyclodextrin-conjugated PEG-PLGA Copolymers

Fabrication of Macroporous Protein-containing Films through the Reverse Emulsions Approach Featuring β-Cyclodextrin-conjugated PEG-PLGA Copolymers

作     者:ji-jie wen 吕宏光 de-e liu 高辉 

作者机构:School of Chemistry and Chemical EngineeringTianjin Key Laboratory of Organic Solar Cells and Photochemical ConversionTianjin University of TechnologyTianjin 300384China 

出 版 物:《Chinese Journal of Polymer Science》 (高分子科学(英文版))

年 卷 期:2016年第34卷第6期

页      面:730-738页

核心收录:

学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程(可授工学、理学学位)] 0703[理学-化学] 

基  金:financially supported by the National Natural Science Foundation of China(Nos.21374079 and 21244004) Program for New Century Excellent Talents in Universities(No.NCET-11-1063) Program for Prominent Young College Teachers of Tianjin Educational Committee 

主  题:β-Cyclodextrin Copolymer Reverse micelles Ordered porous structures Proteins. 

摘      要:A series of β-cyclodextrin-conjugated 4-arm poly(ethylene glycol)-poly(lactide-co-glycolide) (4-arm PEG-PLGA) copolymers were synthesized by a ring-opening polymerization of D,L-lactide and glycolide using 4-arm PEG as initiator, and then conjugated with mono(6-ethylenediamine-6-deoxy)- β-cyclodextrin (CDen) or ethylenediamino-bridged bis- β-CD (BCDen). The chemical structures of copolymers were confirmed by IH-NMR and FTIR spectroscopy. The , β-CD-conjugated PEG-PLGA formed stable reverse micelles due to the formation of fl-CD and bovine serum albumin (BSA) inclusion complexation, which could accommodate BSA in the organic solvent with improved encapsulation efficiency. Moreover, we demonstrated a one-step approach to construct macroporous protein-containing films using these reverse micelles. The films with ordered pore arrays were directly prepared from reverse micelles. Interestingly, the protein was totally located in the whole matrix except for the pores.

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