Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities

作     者：Ya Gao Jian-Chao Chen Xing-Rong Peng Zhong-Rong Li Hai-Guo Su Ming-Hua Qiu 

作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of the Chinese Academy of SciencesBeijing 100049People’s Republic of China Yunnan Key Laboratory of Natural Medicinal ChemistryChinese Academy of SciencesKunming 650201People’s Republic of China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2020年第10卷第3期

页      面：153-161页

学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported by a program of the National Natural Science Foundation of China(Nos.31872675 and 81373288) the cooperation program between Chinese Academy of Sciences and Guangdong Province(2013B09110011). 

主　　题：Momordica charantia Cucurbitane-type triterpene glycosides α-Glucosidase inhibitory activity 

摘      要：Ten cucurbitane-type triterpene glycosides,including five new compounds named charantosides H(1),J(2),K(3),momor-characoside A(4),goyaglycoside-l(5),and five known compounds(6-10),were isolated from the EtOAc extract of Momor-dica charantia fruits.The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses.Configurations of new compounds were determined by ROESY correlations and comparison of their 13C NMR data with literature reported values.All compounds were evaluated for their inhibition againstα-glucosidase,in which compounds 2,5,7,8,9 showed moderate inhibitory activities with IC50 values ranging from 28.40 to 63.26μM comparing with the positive control(acarbose,IC5087.65±6.51μM).