Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases:Schistosomiasis,Trypanosomiasis and Leishmaniasis

作     者：Conrad V.Simoben Fidele Ntie-Kang Sergi H.Akone Wolfgang Sippl 

作者机构：Institute of PharmacyMartin-Luther University of Halle-WittenbergWolfgang-Langenbeck-Str.406120 Halle(Saale)Germany Department of ChemistryFaculty of ScienceUniversity of BueaP.O.Box 63Buea 00237Cameroon Institute of Pharmaceutical Biology and BiotechnologyHeinrich-Heine-UniversityUniversitaetsstrasse1Geb.26.23Duesseldorf 40225Germany Department of ChemistryFaculty of ScienceUniversity of DoualaPO Box 24157Douala 00237Cameroon 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2018年第8卷第3期

页      面：151-169页

学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 070303[理学-有机化学] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学] 

基　　金：German Academic Exchange Services Alexander von Humboldt-Stiftung Center for Visual Science, CVS Deutscher Akademischer Austauschdienst, DAAD 

主　　题：African medicinal plants Leishmaniasis Natural products Parasitic diseases Schistosomiasis Trypanosomiasis 

摘      要：Parasitic diseases continue to represent a threat on a global scale,particularly among the poorest countries in the world.This is particularly because of the absence of vaccines,and in some cases,resistance against available drugs,currently being used for their treatment.In this review emphasis is laid on natural products and scaffolds from African medicinal plants(AMPs)for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases.In the discussion,emphasis has been laid on alkaloids,terpenoids,quinones,flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma,Trypanosoma and Leishmania species.In each subparagraph,emphasis is laid on the compound subclasses with most promising in vitro and/or in vivo activities of plant extracts and isolated compounds.Suggestions for future drug development from African medicinal plants have also been provided.This review covering 167 references,including 82 compounds,provides information published within two decades(1997-2017).