Imprinting methylation and assisted reproductive technology

作     者：Yan HAO Zhi-guo ZHANG Dan HAN Ping ZHOU Yun-xia CAO Zhao-lian WEI Dong-mei JI Bei-li CHEN Wei-wei ZOU Da-wei CHEN Fu-xi ZHU Yan HAO;Zhi-guo ZHANG;Dan HAN;Ping ZHOU;Yun-xia CAO;Zhao-lian WEI;Dong-mei JI;Bei-li CHEN;Wei-wei ZOU;Da-wei CHEN;Fu-xi ZHU;Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University

作者机构：Reproductive Medicine Center Department of Obstetrics and Gynecology the First Affiliated Hospital of Anhui Medical University 

出 版 物：《Journal of Reproduction and Contraception》 (生殖与避孕（英文版）)

年 卷 期：2015年第26卷第2期

页      面：112-120页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by Cultivating Youth Training Programme Fund in the First Affiliated Hospital of Anhui Medical University(2015KJ03) Reserve talented person fund in the First Affiliated Hospital of Anhui Medical University(310100J001165) 

主　　题：imprinting methylation assisted reproductive technology (ART) disoder epigenetics 

摘      要：Assisted reproductive technology （ART） is an important treatment for infertile people of reproductive age and is also known as fertility treatment. The processes of ART involves the isolation, handling and culture of early embryos, which may result in alterations in genomic methylation at specific loci and influence the proper establishment and maintenance of genomic imprints. Recent studies have identified an increased incidence of imprinting disorders via ART. In this article, we reviewed that the ART may be prone to induction of imprinting methylation errors during embryonic development. Further studies are necessary to elucidate the safety of ART in this field.