Onecut transcription factors in retinal development and maintenance

作     者：Darshan Sapkota Xiuqian Mu 

作者机构：Department of Ophthalmology/Ross Eye Institute Department of Biochemistry New York State Center of Excellence in Bioinformatics and Life Sciences SUNY Eye InstituteUniversity at Buffalo 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第6期

页      面：899-900页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：Research in the Mu lab is supported by grants from the National Eye Institute(EY020545) the SUNY/RF Research Collaboration Fund an unrestricted grant from Research to Prevent Blindness 

主　　题：cell Onecut transcription factors in retinal development and maintenance RGCs 

摘      要：The retina and its development： The retina is an essential part of the visual system. A myriad of eye diseases are characterized by retinal degeneration, caused by either genetic or environmental factors. This underscores the importance of studying the genetic and molecular mechanisms that regulate the generation and maintenance of neurons in the mammalian retina. Our recent studies demonstrate that two related transcription factors Onecutl （Ocl） and Onecut2 （0c2） regulate multiple cell fates in the mouse retina, and their absence results in progressive retinal neurodegeneration （Wu et al., 2012, 2013; Sapkota et al., 2014）.