Cannabinomimetric Lipids:From Natural Extract to Artificial Synthesis

作     者：Ya-Ru Gao Yong-Qiang Wang 

作者机构：Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of EducationDepartment of Chemistry&Materials ScienceNorthwest UniversityXi’an 710069People’s Republic of China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2018年第8卷第1期

页      面：1-21页

学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 0901[农学-作物学] 0902[农学-园艺学] 0701[理学-数学] 

基　　金：support from National Natural Science Foundation of China(NSFC-21572178 and NSFC-21702162). 

主　　题：Endocannabinoid Cannabinoid receptors Cannabinomimetric lipids 

摘      要：Endocannabinoid system is related with various physiological and cognitive processes including fertility,pregnancy,during pre-and postnatal development,pain-sensation,mood,appetite,and memory.In the latest decades,an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB1 and CB2.Anandamide was the first reported endogenous metabolite,which adjusted the release of some neurotransmitters through binding to the CB1 or CB2 receptors.Then a series of cannabinomimetric lipids were extracted from marine organisms,which possessed similar structure with anandamide.This review will provide a short account about cannabi-nomimetric lipids for their extraction and synthesis.