Noninherited Factors in Fetal Congenital Heart Diseases Based on Bayesian Network:A Large Multicenter Study

作     者：Yanping Ruan Xiangyu Liu Haogang Zhu Yijie Lu Xiaowei Liu Jiancheng Han Lin Sun Ye Zhang Xiaoyan Gu Ying Zhao Lei Li Suzhen Ran Jingli Chen Qiong Yu Yan Xu Hongmei Xia Yihua He 

作者机构：Department of EchocardiographyMaternal-Fetal Medicine Research Consultation CenterBeijing Anzhen HospitalCapital Medical UniversityBeijing100029China School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China State Key Laboratory of Software Development EnvironmentSchool of Computer Science and EngineeringBeihang UniversityBeijing100191China Department of UltrasoundChongqing Health Center for Women and ChildrenChongqing400013China Department of UltrasoundUrumqi Maternal and Child Health HospitalUrumqi830001China Department of UltrasoundPingxiang Maternal and Child CarePingxiang337055China Department of UltrasoundPeople’s Hospital of RizhaoRizhao276800China Department of UltrasoundXinqiao Hospital Army Medical UniversityChongqing400038China 

出 版 物：《Congenital Heart Disease》 (先天性心脏病（英文）)

年 卷 期：2021年第16卷第6期

页      面：529-549页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：National Key R&D Program of China(2018YFC1002300) 

主　　题：Congenital heart diseases bayesian network risk ratio factor 

摘      要：Background:Current studies have confirmed that fetal congenital heart diseases(CHDs)are caused by various ***,the quantitative risk of CHD is not clear given the combined effects of multiple ***:This cross-sectional study aimed to detect associated factors of fetal CHD using a Bayesian network in a large sample and quantitatively analyze relative risk ratios(RRs).Methods:Pregnant women who underwent fetal echocardiography(N=16,086 including 3,312 with CHD fetuses)were ***-six maternal and fetal factors were obtained.A Bayesian network is constructed based on all variables through structural learning and parameter learning methods to find the environmental factors that directly and indirectly associated with outcome,and the probability of fetal CHD in the two groups is predicted through a junction tree reasoning algorithm,so as to obtain RR for fetal CHD under different exposure factor *** into account the effect of gestational week on the accuracy of model prediction,we conducted sensitivity analysis on gestational week ***:The single-factor analysis showed that the RRs for the numbers of births,spontaneous abortions,and parental smoking were 1.50,1.38,and 1.11(P0.001),*** risk gradually increased with the synergistic effect of ranging from one to more environmental factors *** risk was higher among subjects with five synergistic factors,including the number of births,upper respiratory tract infection during early pregnancy,anemia,and mental stress as well as a history of spontaneous abortions or parental smoking,than in those with less than 5 factors(RR=2.62 or 2.28,P0.001).This result was consistent across the participants grouped by ***:We identified six factors that were directly associated with fetal CHD.A higher number of these factors led to a higher risk of *** findings suggest that it is important to strengthen healthcare and prenatal counseling for women