microRNAs: critical regulators in Th17 cells and players in diseases

作     者：Bin Wei Gang Pei 

作者机构：Laboratory of Molecular Cell BiologyInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2010年第7卷第3期

页      面：175-181页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：We thank Miss C.Liu for critically reading this manuscript.This work was supported by the Shanghai Natural Science Foundation(No.10ZR1435300). 

主　　题：autoimmune diseases microRNAs Th17 cells 

摘      要：microRNAs are a novel group of small,conserved,non-coding RNA molecules that are present in all species.These molecules post-transcriptionally regulate gene expression by targeting mRNAs for degradation or by repressing the translation of the mRNAs.A good understanding of miRNA-mediated gene regulation is critical to gain a comprehensive view of many physiological processes and disease states.Emerging evidence demonstrates that miRNAs play an important role in the differentiation and function of the adaptive immune system.This review provides an overview of the diverse functions of miRNAs in modulating immune responses and in immune cell development,particularly the development of Th17 cells,and explores the involvement of miRNAs in several autoimmune diseases including multiple sclerosis(MS),rheumatoid arthritis(RA),inflammatory bowel disease(IBD)and diabetes.