Drug resistance and combating drug resistance in cancer
作者机构：Department of Biological SciencesOhio UniversityAthensOH 45701USA Interdisciplinary Graduate Program in Molecular and Cellular BiologyOhio UniversityAthensOH 45701USA The Edison Biotechnology InstituteOhio UniversityAthensOH 45701USA Department of Chemistry and BiochemistryOhio UniversityAthensOH 45701USA Department of Biomedical SciencesHeritage College of OsteopathicOhio UniversityAthensOH 45701USA.
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2019年第2卷第2期
页 面：141-160页
学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：John Kopchick
主 题：Cancer stem cells epithelial mesenchymal transition ATP binding cassette transporters extracellular ATP macropinocytosis epigenetics microRNA
摘 要：Cancer is the second leading cause of death in the *** major treatments for cancer management include surgery,cytotoxic chemotherapy,targeted therapy,radiation therapy,endocrine therapy and *** the endeavors and achievements made in treating cancers during the past decades,resistance to classical chemotherapeutic agents and/or novel targeted drugs continues to be a major problem in cancer *** resistance,either existing before treatment(intrinsic)or generated after therapy(acquired),is responsible for most relapses of cancer,one of the major causes of death of the *** among patients and tumors,and the versatility of cancer to circumvent therapies make drug resistance more challenging to deal *** understanding the mechanisms of drug resistance is required to provide guidance to future cancer treatment and achieve better *** this review,intrinsic and acquired resistance will be *** addition,new discoveries in mechanisms of drug resistance will be ***,we will highlight roles of ATP in drug resistance by discussing recent findings of exceptionally high levels of intratumoral extracellular ATP as well as intracellular ATP internalized from extracellular *** complexity of drug resistance development suggests that combinational and personalized therapies,which should take ATP into consideration,might provide better strategies and improved efficacy for fighting drug resistance in cancer.
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