Therapeutic tumor vaccines-a rising star to benefit cancer patients
作者机构：Department of OncologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Key Laboratory of Systems BiologyInstitute of Biochemistry and Cell BiologyShanghai 200031China
出 版 物：《Artificial Intelligence in Cancer》 (癌症中的人工智能（英文）)
年 卷 期：2021年第2卷第3期
页 面：25-41页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Tumor vaccines Tumor cell vaccines Dendritic cell vaccines Peptide vaccines Nucleic acid vaccines
摘 要：Malignant tumors are still a worldwide threat to human *** treatment strategies are constantly evolving,and the advent of tumor immunotherapy has brought up hope to many types of tumors,especially for those that are refractory to conventional therapies including surgery,radiotherapy,and *** vaccines can initiate or amplify an anti-tumor immune response in tumor patients through active immunization,and therefore occupy an important position in tumor *** main types of tumor vaccines include tumor cell vaccines,dendritic cell vaccines,polypeptide vaccines and nucleic acid *** to factors such as poor antigen selection and suppressive tumor microenvironment,earliest tumor vaccines on clinical trials failed to achieve satisfactory clinical ***,with the development of second-generation genome sequencing technologies and bioinformatics tools,it is possible to predict neoantigens generated by tumor-specific mutations and therefore prepare personalized *** article summarizes the global efforts in developing tumor vaccines and highlights several representative tumor vaccines in each category.
维普期刊数据库