Autophagy in dendritic cells
作者机构：Centre d‘Immunologie de Marseille-LuminyInsermU1104CNRS UMR7280MarseilleFrance
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2018年第15卷第11期
页 面：944-952页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：The present work was supported by funding from the Horizon 2020 work program of the Marie Curie Actions grant agreement number 57212 MCNTMTDC(GG) La Ligue Contre le Cancer fellowship(GG) Equipe Labellisee LNCC grant(TL).
主 题：autophagy dendritic cells maturation
摘 要：Autophagy and immunity share the property of being auto-protective for the organism.Autophagy is an important degradation pathway that buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man.Perturbations in autophagy are associated with inflammation and cancer development.Emerging studies have characterized the molecular details regarding how autophagy is controlled by immune cells.Among these,dendritic cells(DCs)are one of the most potent professional antigen-presenting cells critical for the activation of naïve T cells to maintain immune tolerance and drive protective immunity to infection and cancer.DCs undergo functional maturation that can either lead to an immunostimulatory phenotype,as in the context of infection,or to a tolerogenic phenotype associated with immunosuppression to self-antigens,as well as to cancer.An increasing number of recent studies has characterized the involvement of autophagy in DC functions in various physiological and pathological contexts.Here,we provide a comprehensive review of these outcomes and discuss the limitation of the models used and the forefront of the knowledge concerning the crosstalk between autophagy and DC biology.
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