Gut-homing α4β7 CD4+ T cells: potential key players in both acute HIV infection and HIV-associated cancers

作     者：Yang Wang Xiaofan Lu Hao Wu Wei Li 

作者机构：Center of Interventional Oncology and Liver DiseasesBeijing You'an HospitalCapital Medical UniversityBeijing100069China Beijing Key Laboratory for HIV/AIDS ResearchBeijing100069China Center of Infectious DiseaseBeijing You'an HospitalCapital Medical UniversityBeijing100069China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2018年第15卷第2期

页      面：190-192页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

主　　题：α4β7 Th17 acute 

摘      要：During acute human immunodeficiency virus(HIV)infection,depletion of CD4^(+) T cells in the host gut mucosa occurs prior to its occurrence in the peripheral blood and other lymphoid tissues.Expression of integrinα4β7,a gut-homing receptor on CD4^(+) T cells,not only provides a potential receptor for HIV but also plays a critical role in lymphocyte migration from the circulation to the intestine.In our previous study,it was found that circulating gut-homingα4β7 CD4^(+) T cells,including the Th17 and Th1 subsets,were significantly depleted during acute HIV-1 infection.1 Moreover,no gut-homing Treg cells were depleted.Thus,the gut-homing Treg:Th17 ratio was inversely correlated with the CD4 T+cell count.