Systems-level biomarkers identification and drug repositioning in colorectal cancer
作者机构：Department of BioengineeringMarmara UniversityIstanbul 34722Turkey
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第7期
页 面：638-661页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：TUBITAK(Hande Beklen and Kazim Yalcin Arga) No.119S174 Marmara University Research Fund(BAPKO),No.FENC-YLP-120619-0199
主 题：Colorectal cancer Colon cancer Systems biology Biomarker Drug repositioning Omics
摘 要：Colorectal cancer(CRC)is the most commonly diagnosed fatal cancer in both women and men *** ranked second in mortality and third in incidence in *** is difficult to diagnose CRC at an early stage as there are no clinical *** advances in molecular biology,only a limited number of biomarkers have been translated into routine clinical practice to predict risk,prognosis and response to *** the last decades,systems biology approaches at the omics level have gained *** the years,several biomarkers for CRC have been discovered in terms of disease diagnosis and *** the other hand,a few drugs are being developed and used in clinics for the treatment of ***,the development of new drugs is very costly and time-consuming as the research and development takes about 10 years and more than$1 ***,drug repositioning(DR)could save time and money by establishing new indications for existing *** this review,we aim to provide an overview of biomarkers for the diagnosis and prognosis of CRC from the systems biology perspective and insights into DR approaches for the prevention or treatment of CRC.
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