Polymerizable AEE-active Dye with Optical Activity for Fluorescent Nanoparticles Based on Phenothiazine:Synthesis,Self-assembly and Biological Imaging
有光活动为的 Polymerizable AEE 活跃的染料荧光灯基于 Phenothiazine 的 Nanoparticles : 合成,自己组装、生物成像作者机构:School of Materials&Food EngineeringZhongshan InstituteUniversity of Electronic Science&Technology of ChinaZhongshan 528402China School of Materials and EnergyUniversity of Electronic Science&Technology of ChinaChengdu 610054China Department of Chemistrythe Tsinghua Center for Frontier Polymer ResearchTsinghua UniversityBeijing 100084China
出 版 物:《Chinese Journal of Polymer Science》 (高分子科学(英文版))
年 卷 期:2021年第39卷第11期
页 面:1431-1440页
核心收录:
学科分类:0831[工学-生物医学工程(可授工学、理学、医学学位)] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程(可授工学、理学学位)] 0836[工学-生物工程]
基 金:financially supported by the Natural Science Foundation of Guangdong Province(Nos.2018A030313784 and 2021A1515410008) the Colleges and Universities Projects of Guangdong Province(Nos.2020KTSCX180,2020KTSCX184 and 2020ZDZX3027) the National Natural Science Foundation of China(No.51673107) the Climbing Plan of Guangdong Province(No.PDJH2021a0616)
主 题:AEE dye Optical activity RAFT polymerization Long-wave emission Biological imaging
摘 要:In consideration of various advantages such as less harm,higher sensitivity,and deeper imaging depth,etc.,AIE materials with longwave emission are attracting extensive attention in the fields of vascular visualization,organelle imaging,cells tracker,forensic detection,bioprobe and chemosensor,*** this work,a novel fluorescent(R)-PVHMA monomer with chirality and aggregation-induced emission enhancement(AEE)characteristics was acquired through enzymatic transesterification reaction basing on phenothiazine,and its[α]D25℃value was about-6.39°with a 3.08 eV bandgap calculated by the quantum ***,a series of PEG-PVH1 and PEG-PVH2 copolymers with chirality feature were achieved through RAFT polymerization of the obtained(R)-PVHMA and PEGMA with various feed *** the feed molar ratio of(R)-PVHMA increased from 21.5%to 29.6%,its actual molar fractions in the PEG-PVH1 and PEG-PVH2 copolymers accordingly increased from 18.1%to 25.7%.The molecular weight of PEG-PVH1 was about 2.2×10^(4) with a narrow PDI,and their kinetics estimation showed a first-order quasilinear *** aqueous solution,the amphiphilic copolymers PEG-PVH could self-assemble into about 100 nm *** a 90%water solution of H_(2)O and THF mixture,the fluorescence intensity had the maximum value,and the emission wavelength presented at 580 and 630 *** investigation of cytotoxicity and cells uptake showed that PEG-PVH FONs performed outstanding biocompatibility and excellent cells absorption effects,which have great potential in bioimaging application.