CNMa-CNMa receptor at microbiome-gut-brain axis:novel target to regulate feeding decision

作     者：Liyuan Peng Hai-Yan Yin Canhua Huang Liyuan Peng;Hai-Yan Yin;Canhua Huang

作者机构：School of Basic Medical SciencesChengdu University of Traditional Chinese MedicineChengduChina State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengduChina lnternational Collaborative Centre on Big Science Plan for Purinergic SignallingChengdu University of Traditional Chinese MedicineChengduChina Acupuncture and Chronobiology Key Laboratory of Sichuan ProvinceChengduChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第8期

页      面：2275-2277页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from National Key Research and Development Project of China(2020YFA0509400,2020YFC2002705,2019YFC1709000) Guangdong Basic and Applied Basic Research Foundation(2019B030302012),NSFC(81821002,81790251) 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYJC21004) MDT program of State Administration of Traditional Chinese Medicine 

主　　题：CNM expressing 

摘      要：A recent study published in Nature by Kim et *** that the CNMamide(CNMa)-CNMa receptor(CNMaR)axis plays a crucial regulatory role in response to deprivation of diet-and microbiome-derived amino acid in *** detail,gut enterocytes detect and respond to protein limitation through upregulating CNMa expression and communicating with CNMaR-expressing neurons in the brain(Fig.1).