Management of thoracoabdominal neuroblastoma:a 13-year experience

作     者：Chan Hon Chui Anselm Lee 

作者机构：Surgery Centre for ChildrenSingaporeSingapore Children's Haematology and Cancer CentreSingaporeSingapore 

出 版 物：《World Journal of Pediatric Surgery》 (世界小儿外科杂志（英文）)

年 卷 期：2019年第2卷第2期

页      面：47-52页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：neuroblastoma abdominal chemotherapy 

摘      要：background Thoracoabdominal neuroblastoma is a unique surgical *** reviewed our experience focusing on disease patterns and corresponding surgical *** Among 310 patients in our neuroblastoma database,30(9.7%)had thoracoabdominal ***’clinical charts were reviewed and *** disease patterns were identified:solitary thoracoabdominal tumor(group A,n=15)and multifocal tumors in thorax and abdomen(group B,n=15).Operative approaches were categorized based on routes of surgical *** Thirty patients with average age of 4.1(range 0.8-12.8)years were *** received preoperative *** 15 group A patients,four were stage 3 intermediate risk(IR)and 11 were stage 4 high risk(HR).Surgical approaches included single-incision thoracoabdominal approach(n=10),laparotomy-cum-transdiaphragmatic approach(n=3),and laparotomy-cum-thoracotomy approach(n=2).One patient had 10%residual disease and the rest achieved gross total *** complications included chylous ascites(n=3),intestinal obstruction(n=3),pneumonia(n=1),spinal cord infarction(n=1)scoliosis(n=2)and thoracoabdominal nerves palsy(n=3).Among 15 group B patients,all were stage 4 with five IR and 10 *** components were found in the posterior mediastinum(n=7),superior mediastinum(n=4),middle mediastinum(n=1),parietal pleura(n=3)and lungs(n=3).Surgical approaches included multi-incision laparotomy-cum-thoracotomy(n=14)and laparotomy-cum-transdiaphragmatic approach(n=1).Gross total resection was achieved in all *** complications included chylous ascites(n=3).Overall,all nine IR patients survived without evidence of disease and 9(42.8%)HR patients died of *** was no perioperative *** Surgical resection of thoracoabdominal neuroblastoma is feasible and *** its complexity,thoracoabdominal neuroblastoma has comparable treatment outcomes when compared with single-compartmental disease