Study on the spatial distribution patterns of histone modifications in Hippo pathway genes
Study on the spatial distribution patterns of histone modifications in Hippo pathway genes作者机构：College of Science Inner Mongolia Agriculture University Laboratory of Theoretical Biophysics School of Physical Science and Technology Inner Mongolia University The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock Inner Mongolia University
出 版 物：《Biophysics Reports》 (生物物理学报)
年 卷 期：2021年第7卷第1期
页 面：71-79页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：supported by a grant from the Foundation for basic science research of Inner Mongolia Agricultural University (JC2017004) the Doctoral Initial Scientific Research Fund of Inner Mongolia Agricultural University (NDGCC2016-09) Scientific and Technological Research Project of Colleges and Universities in Inner Mongolia (NJZY21473) the National Natural Science Foundation of China (31870838)
主 题：Hippo pathway Embryonic stem cell Histone modification Spatial distribution pattern
摘 要：Hippo pathway can regulate cell division, differentiation and apoptosis, and control the shape and size of organs. To study the distribution patterns of histone modifications of Hippo pathway genes in embryonic stem cells is helpful to understand the molecular regulation mechanism of histone modification and Hippo pathway on stem cell self-renewal. In this study, 19 genes of Hippo pathway including YAP, TAZ, LATS1/2, MST1 and SAV1, and eight histone modifications in embryonic stem cells were chosen to study the spatial distribution patterns of histone modifications. It was found that there were obvious type specificity and the location preference of target regions in the distributions of histone modifications, and H3 K4 me3 and H3 K36 me3 played the most important regulatory roles. Through the correlation analysis of histone modifications, a histone modification functional cluster composed of H3 K4 ac, H3 K4 me3, H3 K9 ac and H3 K27 ac was detected in YAP. In addition, the spatial distribution patterns of histone modifications in Hippo pathway genes were obtained, which provided a new theoretical reference for elucidating the mechanism of histone modifications regulating the gene expression of Hippo pathway, and for revealing the molecular regulatory mechanism of histone modifications affecting the self-renewal of embryonic stem cells by regulating the Hippo pathway.
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