A novel mouse model simulating transurethral laser vaporization prostatectomy

作     者：Heng Zhang Ye Tian Bing Yang Ling-Yue An Shu-Jie Xia Guang-Heng Luo 

作者机构：Medical School of Guizhou UniversityGuiyang 550000China Department of Urology SurgeryGuizhou Province People’s HospitalGuiyang 550002China School of Clinical MedicineGuizhou Medical UniversityGuiyang 55025China School of Clinical MedicineGuangzhou Medical UniversityGuangzhou 510180China Department of UrologyShanghai First People’s HospitalShanghai Jiao Tong UniversityShanghai 201620China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2022年第24卷第2期

页      面：191-194页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：The present study is supported financially by grants from the National Natural Science Foundation of China(No.81860141) the Foundation of Health and Family Planning Commission of Guizhou Province(Gzwjkj-2017-1-032) Guizhou Science-Technology Support Plan Projects(2797) 

主　　题：animal model benign prostatic hyperplasia transurethral resection of the prostate 

摘      要：Benign prostatic hyperplasia(BPH)is a common disease in elderly men,and transurethral laser prostatectomy(TULP)has been widely used in the clinic to remove bladder outlet obstruction caused by *** animal models for wound repair after prostatectomy have many limitations,and there have been no previous reports of a mouse model of ***,this study aimed to establish a novel mouse model of *** healthy adult Kunming(KM)mice received transurethral laser vaporization prostatectomy with a 200-μm thulium *** mice were sacrificed,and wound specimens from the prostatic urethra and bladder neck were harvested at 1 day,3 days,5 days,and 7 days after ***-eosin(HE)and immunohistochemistry were applied to confirm the establishment of the mouse TULP *** day after the surgery,urothelium expressing uroplakin(UPK)was absent in the urethral wound site,and a large number of necrotic tissues were found in the wound *** was no UPK-positive urothelium in the wound 3 days after *** 5 days after surgery,monolayer urothelium expressing UPK was found in the wound site,indicating that the re-epithelization of the wound had been *** the 7th day after surgery,there were multiple layers of urothelium with UPK expression,indicating that the repair was *** is feasible to establish a mouse TULP model by using a microcystoscope system and a 200-μm thulium laser.