Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair

作     者：Robert C.H.Gresham Chelsea S.Bahney J.Kent Leach 

作者机构：UC DavisDepartment of Biomedical EngineeringDavisCAUSA Steadman Phillippon Research InstituteVailCOUSA UCSF Orthopaedic Trauma InstituteSan FranciscoCAUSA UC Davis HealthDepartment of Orthopaedic SurgeryDavisCAUSA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第7期

页      面：1945-1956页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：This work was supported by the National Institutes of Health under award number R01 DE025475 and R01 DE025899 to JKL. 

主　　题：Growth factor Extracellular matrix Spatiotemporal control Tissue engineering Affinity 

摘      要：Therapeutic approaches for musculoskeletal tissue regeneration commonly employ growth factors(GFs)to influence neighboring cells and promote migration,proliferation,or differentiation.Despite promising results in preclinical models,the use of inductive biomacromolecules has achieved limited success in translation to the clinic.The field has yet to sufficiently overcome substantial hurdles such as poor spatiotemporal control and supraphysiological dosages,which commonly result in detrimental side effects.Physiological presentation and retention of biomacromolecules is regulated by the extracellular matrix(ECM),which acts as a reservoir for GFs via electrostatic interactions.Advances in the manipulation of extracellular proteins,decellularized tissues,and synthetic ECM-mimetic applications across a range of biomaterials have increased the ability to direct the presentation of GFs.Successful application of biomaterial technologies utilizing ECM mimetics increases tissue regeneration without the reliance on supraphysiological doses of inductive biomacromolecules.This review describes recent strategies to manage GF presentation using ECM-mimetic substrates for the regeneration of bone,cartilage,and muscle.