Spectrophotometric Simultaneous Determination of Zinc(II), Manganese(II) and Iron(II) in Pharmaceutical Preparations Using OSC-PLS

作     者：Ali NIAZI zadeh YAZDANIPOUR ohammad GOODARZI amidreza KAMKAR Ali RAFINEJAD 

作者机构：Department of Chemistry Faculty of Sciences Azad University of Arak Arak Iran Department of Pharmacy Faculty of Pharmacy Azad University Tehran Iran 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第10期

页      面：1347-1350页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

主　　题：Zinc(Ⅱ) manganese(Ⅱ) iron(Ⅱ) spectrophotometric OSC-PLS pharmaceutical 

摘      要：This work reports the spectrophotometric simultaneous determination of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） in pharmaceutical preparation, using orthogonal signal correctionpartial least squares （OSC-PLS）. All the factors affecting on the sensitivity were optimized and the linear dynamic range for determination of these metals was found. The PLS modeling was used for the multivariate calibration of the spectrophotometric data. The OSC was used for preprocessing of data matrices and the prediction results of model. The experimental calibration matrix was designed by measuring the absorbance over the range 450-570 nm for 21 samples of 0.05-1.05, 0.10-1.10 and 0.05-1.05μg·mL^-1 of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ）, respectively. The RMSEP for zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） using OSC-PLS were 0.0164, 0.0132, 0.0146, respectively. The proposed method was successfully applied the determination of zinc（Ⅱ）, manganese（Ⅱ） and iron（Ⅱ） in pharmaceutical preparations.