Mitochondrial dysfunction and Huntington disease

作     者：Wei-Yan ZHANG Zhen-Lun GU Zhong-Qin LIANG Zheng-Hong QIN 

作者机构：Soochow University School of Life Sciences Department of Pharmacology Soochow University School of Medicine Suzhou 215123 China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2006年第22卷第2期

页      面：129-136页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：中国科学院资助项目(30370506) Specialized Research Fund for the Doctoral Program of Higher Education(20050285017) 

主　　题：mitochondrial dysfunction Huntington disease Huntingtin 

摘      要：Huntington disease （HD） is a chronic autosomal-dominant neurodegenerative disease. The gene coding Huntingtin has been identified, but the pathogenic mechanisms of the disease are still not fully understood. This paper reviews the involvement of mitochondrial dysfunction in pathogenesis of HD.