Molecular Pharmacology of Antinicotinic Activity of Cholinolytic Drugs

作     者：胡文祥 恽榴红 

作者机构：Institute of Pharmacology and Toxicology AMMS Beijing 100850 PRC 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：1994年第39卷第10期

页      面：856-860页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：National Natural Science Foundation of China 

主　　题：anticholinergic compounds acerylcholine receptor s molecular mechanics molecular pharmacology. 

摘      要：Anticholinergic drugs have been widely used for many years in neurological researchand clinical therapy of many diseases, such as parkinsonism, stomachache and theorganophosphorus agents poisoning. But these drugs are antagonists of muscarinicreceptors(M-receptors) and can hardly be used in the treatment of soman poisoning,because it is known in our institute that the potent antimuscarinic and certainantinicotinic activities are necessary for a highly effective drug against Soman poi-soning. In our previous works, we developed a theoretical model for the drug-receptorinteraction deduced from a conformation-activity relationship (CAN) of classic