Molecular mechanisms of growth depression in broiler chickens(Gallus Gallus domesticus)mediated by immune stress:a hepatic proteome study

作     者：Aijuan Zheng Anrong Zhang Zhimin Chen Shoaib Ahmed Pirzado Wenhuan Chang Huiyi Cai Wayne L.Bryden Guohua Liu Aijuan Zheng;Anrong Zhang;Zhimin Chen;Shoaib Ahmed Pirzado;Wenhuan Chang;Huiyi Cai;Wayne L.Bryden;Guohua Liu

作者机构：Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural AffairsInstitute of Feed ResearchChinese Academy of Agricultural SciencesNo.12 Zhongguancun south streetHaidian districtBeijing 100081China School of Agriculture and Food SciencesUniversity of QueenslandGattonQLD 4343Australia 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2021年第12卷第4期

页      面：1498-1516页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：Sponsored by National Natural Science Foundation of China(grant no.31101731) National Key Research and Development Program of China(No.2018YFD0500600) The Agricultural Science and Technology Innovation Program(ASTIP) 

主　　题：Broiler chickens Hepatic proteome Immune stress Lipopolysaccharide 

摘      要：Background:Immunological stress decreases feed intake,suppresses growth and induces economic ***,the underlying molecular mechanism remains ***-free liquid chromatography and mass spectrometry(LC-MS)proteomics techniques were employed to investigate effects of immune stress on the hepatic proteome changes of Arbor Acres broilers(Gallus Gallus domesticus)challenged with Escherichia coli lipopolysaccharide(LPS).Results:Proteomic analysis indicated that 111 proteins were differentially expressed in the liver of broiler chickens from the immune stress *** these,28 proteins were down-regulated,and 83 proteins were up-regulated in the immune stress *** analysis showed that immune stress upregulated the expression of hepatic proteins involved in defense function,amino acid catabolism,ion transport,wound healing,and hormone ***,immune stress increased valine,leucine and isoleucine degradation ***:The data suggests that growth depression of broiler chickens induced by immune stress is triggered by hepatic proteome alterations,and provides a new insight into the mechanism by which immune challenge impairs poultry production.