Sesquiterpenes from Carpesium longifolium

作     者：YANG Chao YUAN Cheng-Shan JIA Zhong-Jian 

作者机构：State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 

出 版 物：《有机化学》 (Chinese Journal of Organic Chemistry)

年 卷 期：2003年第23卷第Z1期

页      面：449-449页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Chinese traditional medicine structural elucidation sesquiterpene lactones Carpesium longifolium cytotoxic activity ovarian carcinoma hepatoma cell 

摘      要： The genus Carpesium (Compositae) with only 21 species is widely distributed in Asia, mainly in the southwest ern mountainous regions of China. The seeds, roots, leaves and stems of some Carpesium species have long been used as Chinese traditional medicine for hemostatic, vermifuge, anti-inflammatory and detoxication properties. [1,2]Here, we report the first phytochemical investigation of Carpesium longifolium Chen et C. M. Hu, which led to the isolation and structural elucidation of four new sesquiterpene lactones 1 ～ 4 and five known compounds 5 ～ 9, the cy totoxic activity test of three compounds 5, 6 and 7, and compounds 5 and 7 exhibited significant cytotoxic activity against cultured SMMC-7721 (human hepatoma cell) and HO-8910 (human ovarian carcinoma cell).……