Integration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in aging mice with type 2 diabetes mellitus
Integration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in aging mice with type 2 diabetes mellitus作者机构:School of Clinical MedicineGansu University of Chinese MedicineLanzhouGansu 730000China Key Laboratory of Traditional Chinese Herbs and Prescription Innovation and Transformation of Gansu ProvinceGansu University of Chinese MedicineLanzhouGansu 730000China
出 版 物:《Chinese Medical Journal》 (中华医学杂志(英文版))
年 卷 期:2022年第135卷第2期
页 面:247-249页
核心收录:
学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金:This work was supported by grants from the National Natural Science Foundation of China(Nos.81760835,82060829) Postgraduate Innovation Fund of Gansu University of Chinese Medicine(No.CX2020-45) Natural Science Foundation of Gansu Province(No.1606RJZA192)
摘 要:To the Editor:Aging can cause changes in human metabolic capacity[1]and metabolic syndrome is one of the important causes of type 2 diabetes mellitus(T2DM).In recent years,T2DM has become one of the top ten killers of humans.[2]T2DM has been reported in≥25%of the population aged over 65 years.[3]The liver is the most important metabolic center and its metabolic disorders are associated with T2DM.