Fabrication, Crosslinking and in vitro Biocompatibility of a Novel Degradable Nano-structure Urethral Tubular Scaffold
Fabrication, Crosslinking and in vitro Biocompatibility of a Novel Degradable Nano-structure Urethral Tubular Scaffold作者机构：Department of Urologythe First Hospital of Jilin UniversityChangchun 130021P.R.China State Key Laboratory of Polymer Physics and ChemistryChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022P.R.China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2012年第28卷第5期
页 面：912-915页
核心收录：
学科分类：080503[工学-材料加工工程] 07[理学] 08[工学] 070205[理学-凝聚态物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学]
基 金：Supported by the National Natural Science Foundation of China(No. 50973043)
主 题：Poly(lactic-co-glycolic acid) Urethral scaffold Degradable Electrospin Crosslinking
摘 要：A degradable poly（lactic-co-glycolic acid, LA：GA=80：20）（PLGA） urethral tubular scaffold was fabricated by electrospinning. In order to enhance the mechanical properties, the scaffold was crosslinked with glutaraldehyde. The structure and properties of the crosslinked scaffolds were investigated by the mechanical property testing, scanning electron microscopy（SEM）, degradability test in vitro and 3-（4,5）-dimethylthiahiazo（-z-yl）-3,5-diphenytetrazo- liumromide（MTT）. The results show that the scaffold has the nano-structure. The pore size and the porosity are suitable for cell seeding, growth and extracellular matrix production. Although influenced by the crosslinking slightly, the pore size and the porosity could still support cell proliferation and tissuse formation. The mechanical properties are remarkably increased by the crosslinking of glutaraldehyde, and it could meet the demands of a urethral stent. The scaffold could completely collapse within 70 d. The results of the biocompatibility test show that the PLGA scaffold had no cytotoxicity.
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