Denting Nanospheres with a Short Peptide

作     者：Sha Lin Hui Sun Erik Jan Cornel Jin-Hui Jiang Yun-Qing Zhu Zhen Fan Jian-Zhong Du Sha Lin;Hui Sun;Erik Jan Cornel;Jin-Hui Jiang;Yun-Qing Zhu;Zhen Fan;Jian-Zhong Du

作者机构：Department of OrthopedicsShanghai Tenth People's HospitalTongji UniversityShanghai 200072China Department of Polymeric MaterialsSchool of Materials Science and EngineeringTongji UniversityShanghai 201804China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2021年第39卷第12期

页      面：1538-1549页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 0817[工学-化学工程与技术] 070304[理学-物理化学(含∶化学物理)] 08[工学] 070205[理学-凝聚态物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：by the National Science Fund for Distinguished Young Scholars,NSFC(No.21925505) Z.F.is supported by the National Natural Science Foundation of China(Nos.51803152,22075212) the program for professor of special appointment(Eastern Scholar)at Shanghai institutions of higher learning and Natural Science Foundation of Shanghai(19ZR1478800) Y.Z.is supported by the National Natural Science Foundation of China(No.51903190)and Shanghai Pujiang Program(No.19PJ140960) EJ.C.is supported by the China Postdoctoral Science Foundation(No.2020M671197) 

主　　题：Dented nanospheres Homopolymer Short peptide Hydrogen bonding π-πStacking 

摘      要：Dented n anospheres show promisi ng potential in drug delivery,nano motors,***,it is still challe nging to prepare them by homopolymer self-assembly because of the strict structural requirements of the ***,we propose a strategy for preparing dented nano spheres from homopolymers by co-assembly with a short *** were co-assembled from poly(2-hydroxy-3-((4-(ethoxycarbonyl)phenyl)amino)propyl methacrylate)(PHBzoMA59)and(S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpro-panamido)-3-phenyIpropanoic acid(Fmoc-FF-OH).PHBzoMA homopolymers can only self-assemble into nanospheres without dent,and the addition of a short peptide in troduced hydroge n bondi ng and complementary π-π stacki ng interactions led to the final dented nano sphere *** weight fracti ons of the short peptide can be adjusted to regulate the final *** was con firmed that the radius of curvature of the dent on the surface was related to the organic bubble inside the protospheres prepared at critical aggregation concentration(CAC).The orga nic bubble can be adjusted by altering the kind of orga nic solve nt and solution pH,which allowed control over the dented nano sphere *** use of differe nt orga nic solve nts with various polarities allows adjustment of the interfacial tension,and hence the denting *** degree can also be controlled by manipulating the solution pH to(de)protonate the short peptide and ***,the versatility of this method was highlighted by using a differe nt homopolymer and the applicability of the resulting den ted nanospheres was demonstrated by decoration with gold ***,this study provided important insights and a new simple strategy to prepare den ted n anospheres in a con trolled fashion.