The influence of reduced graphene oxide on stem cells:a perspective in peripheral nerve regeneration
作者机构：Department of OrthopedicsShanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yishan RoadShanghai 200233China Shanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration600 Yishan RoadShanghai 200233China Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine600 Yishan RoadShanghai 200233China College of Fisheries and Life ScienceShanghai Ocean University999 Metro loop Road ShanghaiChina
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2021年第8卷第4期
页 面：88-96页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：The study was sponsored by the Shanghai Sailing Program(No.20YF1436000) Projects of National Natural Science Foundation of China(Grant Nos 82002290 and 81830076) Municipal Hospital Newly-developing Cutting-edge Technologies Joint Research Program of Shanghai Shenkang Hospital Development Center(No.SHDC12018130) Special Fund for Research on People’s Livelihood(Medical Treatment and Public Health)of Shanghai Pudong Science,Technology and Economic Commission Scientific and Technological Development Fund(No.PKJ2018-Y52) Shanghai Pudong Health Commission Special Program for Clinical Research in the Health Industry(No.PW2018E-01)
主 题：reduced graphene oxide nerve regeneration tissue engineering biomaterials stem cell
摘 要：Graphene and its derivatives are fascinating materials for their extraordinary electrochemical and mechanical *** recent decades,many researchers explored their applications in tissue engineering and regenerative *** graphene oxide(rGO)possesses remarkable structural and functional resemblance to graphene,although some residual oxygen-containing groups and defects exist in the *** structure holds great potential since the remnantoxygenated groups can further be functionalized or ***,oxygen-containing groups can improve the dispersion of rGO in organic or aqueous ***,it is preferable to utilize rGO in the production of composite *** rGO composite scaffolds provide favorable extracellular microenvironment and affect the cellular behavior of cultured cells in the peripheral nerve *** the one hand,rGO impacts on Schwann cells and neurons which are major components of peripheral *** the other hand,rGO-incorporated composite scaffolds promote the neurogenic differentiation of several stem cells,including embryonic stem cells,mesenchymal stem cells,adipose-derived stem cells and neural stem *** review will briefly introduce the production and major properties of rGO,and its potential in modulating the cellular behaviors of specific stem ***,we present its emerging roles in the production of composite scaffolds for nerve tissue engineering.
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